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chimeric antigen receptor (CAR) T-cell therapy

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00:55 Aug 18, 2021
English to Japanese translations [PRO]
Medical - Medical (general)
Additional field(s): Biology (-tech,-chem,micro-), Medical: Pharmaceuticals
English term or phrase: chimeric antigen receptor (CAR) T-cell therapy
Definition from American Cancer Association:
Chimeric antigen receptor (CAR) T-cell therapy is a promising new way to get immune cells called T cells (a type of white blood cell) to fight cancer by changing them in the lab so they can find and destroy cancer cells. CAR T-cell therapies are sometimes talked about as a type of gene or cell therapy, or immune effect cell therapy.

Example sentence(s):
  • Chimeric antigen receptor (CAR) T-cell therapy has had great success in treating patients with relapsed or refractory B-cell malignancies, with CD19-targeting therapies now approved in many countries. However, a subset of patients fail to respond or relapse after CD19 CAR T-cell therapy, in part due to antigen loss, which has prompted the search for alternative antigen targets. Research Square
  • Chimeric antigen receptor (CAR) T-cell therapy represents a major advancement in personalized cancer treatment. In this strategy, a patient's own T cells are genetically engineered to express a synthetic receptor that binds a tumor antigen. CAR T cells are then expanded for clinical use and infused back into the patient's body to attack and destroy chemotherapy-resistant cancer. PubMed
  • In the past 5 years, knowledge of immunology in thoracic cancers has greatly improved. The results observed with immunotherapy are encouraging. For example, in patients with stage 4 non–small cell lung cancer, 5-year survival was previously 2%. That survival rate has now increased to approximately 20% with the use of checkpoint blockade immunotherapy. Similarly, early data from our trial combining chimeric antigen receptor (CAR) T-cell therapy and checkpoint blockade in mesothelioma were promising. Hematology & Oncology
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Question posted on behalf of translation team:
GBK medical and pharma specialistsGBK medical and pharma specialists


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Summary of translations provided
5キメラ抗原受容体（CAR）T細胞療法
Kayoko Kimura


  

Translations offered


12 hrs   confidence: Answerer confidence 5/5
キメラ抗原受容体（CAR）T細胞療法


Definition from 日本生化学会:
chimeric antigen receptor＝キメラ抗原受容体
T-cell therapy=T細胞療法
上記の別々な言葉、および結合した言葉は既に使われています。

Example sentence(s):
Kayoko Kimura
United States
Local time: 03:52
Native speaker of: Native in JapaneseJapanese
PRO pts in category: 111
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