Glossary entry (derived from question below)
English term or phrase:
Target Potency Vaccine
Spanish translation:
vacuna de potencia objetivo
Added to glossary by
Eloisa Anchezar
Feb 15, 2021 18:35
3 yrs ago
24 viewers *
English term
Target Potency Vaccine
English to Spanish
Medical
Other
Validation of the in vitro ELISA potency test
hace referencia al objetivo de potencia de la vacuna??
Reagents/Biologicals to be used as samples in the Optimization and Verification Studies
Material Name
Section of Protocol for use
Identification/Description
Subpotent Vaccine (0.8)
Accuracy/Precision Discrimination
MR 49004-300 (300FTU)
MR diluted to an RP target of approximately 0.8.
Potent Vaccine (120%)
Accuracy/Precision Discrimination
Final product vaccine diluted to approximately +20% of efficacy (approximately 360FTU)
Target Potency Vaccine (Final Product)
Note: formulation matrix for all vaccine samples tested are representative of the commercial vaccine.
gracias!!
Reagents/Biologicals to be used as samples in the Optimization and Verification Studies
Material Name
Section of Protocol for use
Identification/Description
Subpotent Vaccine (0.8)
Accuracy/Precision Discrimination
MR 49004-300 (300FTU)
MR diluted to an RP target of approximately 0.8.
Potent Vaccine (120%)
Accuracy/Precision Discrimination
Final product vaccine diluted to approximately +20% of efficacy (approximately 360FTU)
Target Potency Vaccine (Final Product)
Note: formulation matrix for all vaccine samples tested are representative of the commercial vaccine.
gracias!!
Proposed translations
(Spanish)
| 4 | vacuna de potencia objetivo |
Daniel Delgado
|
| 3 | vacuna de eficacia objetivo |
Marcelo Viera
|
Proposed translations
2 days 17 hrs
Daniel Delgado
Argentina
Argentina
Native in Spanish
Argentina
Technical translator, Chem.eng., IT pro
Native in: Spanish (Variants: Latin American, Rioplatense, Standard-Spain, Argentine)
Works in: English to Spanish, Spanish
Related KudoZ points
:
136
Selected
vacuna de potencia objetivo
Potencia y eficacia son conceptos distintos en inmunología. Potency se traduce como potencia.
https://vichsec.org/en/outreach-forum/index.php?option=com_a...
"Efficacy vs Potency
Efficacy (immunogenicity):
-Direct effect of a treatment on an individual subject
-Pivotal host animal vaccination-challenge study
Potency:
-Serial or batch measure
-Direct or indirect"
https://pubmed.ncbi.nlm.nih.gov/12782051/
"Because of the complexity of pathogenic processes and associated immune responses, potency tests may not always directly predict the effectiveness of a vaccine. Thus, vaccines that pass control potency testing may not always provide adequate efficacy."
" Also, the effects of the dose and duration of antigen exposure as well as the nature of antigen presentation and generation of extrinsic cytokines could be characterised and correlated to vaccine potency as additional indicators of vaccine efficacy. "
https://vichsec.org/en/outreach-forum/index.php?option=com_a...
"Efficacy vs Potency
Efficacy (immunogenicity):
-Direct effect of a treatment on an individual subject
-Pivotal host animal vaccination-challenge study
Potency:
-Serial or batch measure
-Direct or indirect"
https://pubmed.ncbi.nlm.nih.gov/12782051/
"Because of the complexity of pathogenic processes and associated immune responses, potency tests may not always directly predict the effectiveness of a vaccine. Thus, vaccines that pass control potency testing may not always provide adequate efficacy."
" Also, the effects of the dose and duration of antigen exposure as well as the nature of antigen presentation and generation of extrinsic cytokines could be characterised and correlated to vaccine potency as additional indicators of vaccine efficacy. "
4 KudoZ points awarded for this answer.
Comment: "Gracias!!!"
1 hr
Marcelo Viera
Uruguay
Uruguay
Native in Spanish
Uruguay
Technical Translations Specialist
Native in: Spanish
Works in: English to Spanish, Spanish to English
Related KudoZ points
:
12
vacuna de eficacia objetivo
Potency requirements
The eighth report of the WHO Expert Committee on Rabies suggested that inactivated veterinary vaccines with a potency of less than 1.0 IU per dose, as measured by the NIH test, should not be licensed or released unless an adequately designed experiment has demonstrated a duration of immunity of at least one year in the species for which the vaccine is to be used.
The potency of live and inactivated vaccines should be ascertained at intervals after they have been distributed. Inactivated vaccine, even in liquid form, and lyophilized modified live-virus vaccines are relatively stable when stored under proper conditions. To verify that storage conditions are adequate, it is recommended that samples from the field that are approaching their expiry date be tested using the methods applied to newly manufactured products.
Note from asker:
| muchas gracias Marcelo por toda tu ayuda! |
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