HEK assay amenable mutations
Serbian translation: mutacije reaktivne na osnovu analize sa ćelijama bubrega ljudskog embriona
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| 18:22 Nov 18, 2022 |
| English to Serbian translations [PRO] Medical - Medical: Pharmaceuticals / pharmacological tests | |||||||
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|  Selected response from: Milan Nesic | ||||||
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| 4 | mutacije reaktivne na osnovu analize sa ćelijama bubrega ljudskog embriona |
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| HEK = |
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Answers
4 hrs confidence: 
mutacije reaktivne na osnovu analize sa ćelijama bubrega ljudskog embriona Explanation: Tj. mutacije za koje se, na osnovu analize (u skladu sa dobrom laboratorijskom praksom) sa (genetski modifikovanim) ćelijama bubrega ljudskog embriona, pokaže da reaguju na terapiju. "Amenability is determined by an in vitro, good laboratory practice (GLP)-validated assay using HEK293 cells (GLP-HEK assay)" "The term ‘amenable mutation’ is used to describe certain mutations of the galactosidase alpha gene (GLA), found in people with Fabry disease, which respond to treatment with Galafold (migalastat)." -------------------------------------------------- Note added at 2 days 7 hrs (2022-11-21 01:56:30 GMT) -------------------------------------------------- Još bolji prevod za "amenable" bi bio "responzivne". https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6656697/ https://www.drugs.com/medical-answers/amenable-mutation-3560832/ |
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Reference comments
2 hrs peer agreement (net): +1 |
| Reference: HEK = Reference information: report from two phase 2 clinical studies - NCBI https://www.ncbi.nlm.nih.gov › articles › PMC3527132 by DP Germain · 2012 · Cited by 127 — Fabry disease (FD) is a genetic disorder resulting from deficiency of ... HEK-293 = transfection assay in**** Human Embryonic Kidney***-293 cells, ... |
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