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Sep 27, 2023 14:00
8 mos ago
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English term
(Z)-N-(2-chloroethyl)acetimidoyl chloride dichlorophosphate
English to French
Tech/Engineering
Chemistry; Chem Sci/Eng
brevet chimie
A process for the preparation of solabegron hydrochloride comprising:
a. coupling (3-nitrophenyl)boronic acid and methyl 3- bromobenzoate with a coupling agent to form 3’-amino-[1,1’-biphenyl]-3-carboxylate;
b. contacting the 3’-amino-[1,1'-biphenyl]-3-carboxylate from step a. with (Z)-N-(2-chloroethyl)acetimidoyl chloride dichlorophosphate to form methyl (E)- 3’-N-(2-chloroethyl)acetimiamido-[1,1'-biphenyl]-3-carboxylate hydrochloride;
c. contacting the methyl (E)-3’-N-(2-chloroethyl)acetimiamido- [1,1’-biphenyl]-3-carboxylate hydrochloride of step b. with an saturated aqueous base to form 3’-(2’methl-4,5-dihydro-1H-imidazol-l-yl)-[1,1']biphenyl-3-carboxylate;
a. coupling (3-nitrophenyl)boronic acid and methyl 3- bromobenzoate with a coupling agent to form 3’-amino-[1,1’-biphenyl]-3-carboxylate;
b. contacting the 3’-amino-[1,1'-biphenyl]-3-carboxylate from step a. with (Z)-N-(2-chloroethyl)acetimidoyl chloride dichlorophosphate to form methyl (E)- 3’-N-(2-chloroethyl)acetimiamido-[1,1'-biphenyl]-3-carboxylate hydrochloride;
c. contacting the methyl (E)-3’-N-(2-chloroethyl)acetimiamido- [1,1’-biphenyl]-3-carboxylate hydrochloride of step b. with an saturated aqueous base to form 3’-(2’methl-4,5-dihydro-1H-imidazol-l-yl)-[1,1']biphenyl-3-carboxylate;
Reference comments
1 hr
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comment
dear oh dear, I can't even find this online, where does that leave us?
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Note added at 1 час (2023-09-27 15:10:34 GMT)
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oh yes, only one hit though
US10065922B2 - Solabegron zwitterion and uses thereof
Google Patents
https://patents.google.com › patent
The (Z)—N-(2-chloroethyl)acetimidoyl chloride dichlorophosphate was added without purification to methyl 3′-nitro-[1,1′-biphenyl]-3-carboxylate to yield methyl ...
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Note added at 1 час (2023-09-27 15:17:11 GMT)
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I think I should leave this one well alone, way above my pay grade:)
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Note added at 1 час (2023-09-27 15:10:34 GMT)
--------------------------------------------------
oh yes, only one hit though
US10065922B2 - Solabegron zwitterion and uses thereof
Google Patents
https://patents.google.com › patent
The (Z)—N-(2-chloroethyl)acetimidoyl chloride dichlorophosphate was added without purification to methyl 3′-nitro-[1,1′-biphenyl]-3-carboxylate to yield methyl ...
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Note added at 1 час (2023-09-27 15:17:11 GMT)
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I think I should leave this one well alone, way above my pay grade:)
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