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high concentration of hemoglobin (high dose hook effect). Interpretation of results. (presence of control line indicates proper performance ...
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Second it must be kept in mind thatvery high concentrations of human hemoglobin in the sample may lead tonegative test results – a phenomenon known as high dose hook effect (prozoneeffect).

"prozone"
Poglavlje: 9b
"Prozone" je stanje neravnoteže između relativnih koncentracija antigena i protutijela. Npr. u RPR testu za sifilis, bolesnici sa znatnim suviškom protutijela mogu imati lažno negativan test, iako im se u organizmu nalaze brojna antitreponemska protutijela. U takvom slučaju, pri izraženoj sumnji na sifilis, serum bolesnika se mora razrijediti i tada ponoviti isti test.

Fenomen prozone – pojava negativnih rezultata (nema precipitata), dakle u vi{ku su ili Ag ili At. Prozone phenomenon

prozone /pro·zone/ (pro´zon) the phenomenon exhibited by some sera, in which agglutination or precipitation occurs at higher dilution ranges, but is not visible at lower dilutions or when undiluted.

Dorland's Medical Dictionary for Health Consumers. © 2007 by Saunders, an imprint of Elsevier, Inc. All rights reserved.

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pro·zone (przn)
n.
The phenomenon in which mixtures of specific antigen and antibody do not agglutinate or precipitate visibly because of an excess of either antibody or antigen.


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Note added at 6 days (2007-03-20 16:38:57 GMT)
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q Smanjiti učinak razrjeđivanja da se oslabi ... bi “prozonski” učinci bili minimalni. Ana-. lizama u jednom stupnju, koje su sklonije ... dakle bolje mozda i prozonski učinak