chimeric antigen receptor (CAR) T-cell therapy

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00:54 Aug 18, 2021

English to Bulgarian translations [PRO]
Medical - Medical (general)
Additional field(s): Biology (-tech,-chem,micro-), Medical: Pharmaceuticals

English term or phrase: chimeric antigen receptor (CAR) T-cell therapy

Definition from American Cancer Association:
Chimeric antigen receptor (CAR) T-cell therapy is a promising new way to get immune cells called T cells (a type of white blood cell) to fight cancer by changing them in the lab so they can find and destroy cancer cells. CAR T-cell therapies are sometimes talked about as a type of gene or cell therapy, or immune effect cell therapy.

Example sentence(s):

Chimeric antigen receptor (CAR) T-cell therapy has had great success in treating patients with relapsed or refractory B-cell malignancies, with CD19-targeting therapies now approved in many countries. However, a subset of patients fail to respond or relapse after CD19 CAR T-cell therapy, in part due to antigen loss, which has prompted the search for alternative antigen targets. Research Square
Chimeric antigen receptor (CAR) T-cell therapy represents a major advancement in personalized cancer treatment. In this strategy, a patient's own T cells are genetically engineered to express a synthetic receptor that binds a tumor antigen. CAR T cells are then expanded for clinical use and infused back into the patient's body to attack and destroy chemotherapy-resistant cancer. PubMed
In the past 5 years, knowledge of immunology in thoracic cancers has greatly improved. The results observed with immunotherapy are encouraging. For example, in patients with stage 4 non–small cell lung cancer, 5-year survival was previously 2%. That survival rate has now increased to approximately 20% with the use of checkpoint blockade immunotherapy. Similarly, early data from our trial combining chimeric antigen receptor (CAR) T-cell therapy and checkpoint blockade in mesothelioma were promising. Hematology & Oncology

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Summary of translations provided

Терапия с t-клетки с химерен антигенен рецептор

Mihail Mateev

Translations offered

4 hrs confidence:

Терапия с t-клетки с химерен антигенен рецептор

Definition from https://medguide.bg:
Т-клетките с химерен антигенен рецептор представляват имунни клетки, които са генетично модифицирани да експресират синтетичен рецептор. Химерните антигенни рецептори (CARs) са протеини, насочващи Т-клетките към специфичен антиген. Наричат се химерни, тъй като комбинират както антиген-свързващи, така и Т-клетъчнo-активиращи функции.

Example sentence(s):

Abecma е генетично модифициран автоломен химерен антигенен рецептор (CAR) Т-клетъчна терапия и първата клетъчна генна терапия за лечение на възрастни пациенти с множествен миелом . Всяка доза Abecma се създава чрез събиране на собствени Т-клетки на пациента (т.е. бели кръвни клетки, които помагат на организма да се бори с инфекциите) и генетично ги модифицира, така че да включват нов ген, който помага на организма да насочи и убие клетките на миелома. След това тези модифицирани имунни клетки се вливат обратно в кръвта на пациента. - https://onconavigator.info

Explanation:
Други възможни варианти за превод:
car t-клетъчна терапия

Mihail Mateev
Bulgaria
Local time: 18:08
Native speaker of:

Bulgarian
PRO pts in category: 81

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