Oct 28, 2020 11:18
3 yrs ago
21 viewers *
Czech term
United Kingdom
Native in: English (Variant: British) 
Works in: Greek to English, Czech to English, Slovak to English, and 1 more.
v koncovém článku
Czech to English
Medical
Medical (general)
Inhibitory protonové pumpy snižují sekreci kyseliny solné v koncovém článku, tedy na všechny podněty (stimulaci gastrinem, histaminem i cholinergní stimulací). Jedná se o nejúčinnější léčbu, jsou schopny udržet pH v žaludku nad 4 ...
What do they mean by "v koncovém článku" here?
What do they mean by "v koncovém článku" here?
Proposed translations
(English)
| 3 | locally/at the site of action |
Martin Janda
|
| 4 | at the terminal stage |
Jiri Lonsky
|
| 4 | final step |
Sarka Lhotak
|
| 3 | final (common) pathway |
Andrzej Ziomek
|
Proposed translations
6 mins
Martin Janda
Czech Republic
Czech Republic
Native in Czech
Specializes in field
Czech Republic
Related KudoZ points
:
158
Selected
locally/at the site of action
What they mean is that the drug targets the cells producing the acid directly rather than affecting any regulating mechanisms - hormones and the like.
4 KudoZ points awarded for this answer.
Comment: "Thanks everyone, and sorry for the late grading!
This is the version I used."
24 mins
Jiri Lonsky
Czech Republic
Czech Republic
Native in Czech
&
English
Specializes in field
Czech Republic
Bilingual native Czech medical expert
Native in: Czech 
, English
Works in: English to Czech, Czech to English
Related KudoZ points
:
211
at the terminal stage
I believe they mean that the PPI regulates HCl production at the very end of the process, which means that it works universally, regardless of what triggered the HCl production upstream the regulatory pathway. For more details, see the reference.
2 hrs
Sarka Lhotak
Canada
Canada
Native in Czech
&
English
Specializes in field
Canada
Biomedical and scientific background.
Native in: Czech , English
Works in: Czech to English, English to Czech
Related KudoZ points
:
75
5 days
Andrzej Ziomek
Poland
Poland
Specializes in field
Poland
Jack of all trades Master of translation
Native in: Polish
Works in: English to Polish, Polish to English
Related KudoZ points
:
4
final (common) pathway
Just another option - not quite word-for-word
'Proton pump inhibitors reduce acid secretion by inhibiting its final (common) pathway, ...'
'Proton pump inhibitors reduce acid secretion by inhibiting its final (common) pathway, ...'
Example sentence:
The proton pump (H+/K+-ATPase) is the final common pathway for acid secretion in gastric parietal cells, and inhibition of the pump blocks acid secretion almost completely
Reference:
https://www.sciencedirect.com/topics/biochemistry-genetics-and-molecular-biology/proton-pump
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