3.2.3. Build an environmentally physiologically centered
research program in ASCs as a platform for investigating
the EMR/RFR-ASC linkage
This review has been structured around the physiological parallels between ASCs and the impacts of EMF/RFR.
What is missing from the autism research agenda is some
cross-study of these two bodies of research evidence. To
do this we will need both a recognition of the importance
of these risks, and a collaborative multi-site research program centered around a “middle-out” physiological approach
[314] that can transcend the limits of the gene-brain-behavior
agenda that has dominated ASC research, by incorporating
this now clearly limited approach into a broader framework
[315]. This still dominant gene-brain-behavior approach has
been based on an expectation of linear mapping across the
levels on which it focuses, but instead the systems involved
appear to be much more complex. The middle-out approach
is an emerging more inclusive framework in systems biology
that can incorporate complexity and nonlinear, multi-scale
modeling [316–320]. The physiological levels largely left out
in the gene-only approach are critically important to helping people with ASCs because they will help not only with
understanding how environment impacts function but also
with identifying leverage points.
http://www.marthaherbert.org/library/Herbert-Sage-2013-Autis...