Sep 4, 2020 00:54
3 yrs ago
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English term
co-crystals
GBK
English to Croatian
Medical
Medical (general)
Definition from
Pharma IQ:
Co-Crystals are defined as a technology used to enhance solubility, stability and the IP position with respect to the development of active pharmaceutical ingredients (APIs). Exploring the co-crystallization potential around an API increases the intellectual property protection over a particular drug product; thus, reducing the risk of costly litigation and market erosion.
Example sentences:
In addition space is not limited to binary combinations (acid-base pairs) since tertiary and quaternary co-crystals are realistic one (Indian J Pharm Sci.)
In addition, co-crystals of the muscle relaxant metaxalone have been reported to improve preclinical in vivo bioavailability. (Dove Press)
As part of an effort to clarify and help advance the development of pharmaceutical co-crystals, the US Food and Drug Administration (FDA) on Tuesday released revised draft guidance providing information on the appropriate classification of co-crystal solid-state forms, the data that should be submitted to support the classification and the regulatory implications of such a classification. (Regulatory Focus™)
Proposed translations
(Croatian)
| 4 +1 | kokristali |
Kate Perak
|
Change log
Aug 22, 2020 00:53: changed "Kudoz queue" from "In queue" to "Public"
Sep 4, 2020 00:54: changed "Stage" from "Preparation" to "Submission"
Sep 7, 2020 01:55: changed "Stage" from "Submission" to "Selection"
Sep 14, 2020 01:55:
Oct 4, 2020 01:55:
Nov 3, 2020 01:55:
Proposed translations
+1
9 hrs
Kate Perak
Croatia
Croatia
Croatia
HR, EN, IT, ES --> MA in Translation
Native in: Croatian 
Works in: English to Croatian, Italian to Croatian, Spanish to Croatian, and 2 more.
Related KudoZ points
:
60
kokristali
Definition from
Repozitorij ZIR:
Oblici višekomponentnih supramolekulskih sustava građeni od nenabijenih farmakološki aktivnih molekula i farmakološki prihvatljivih molekula sučinitelja (koformera), koji su u kristalu povezani međumolekulskim privlačnim silama poput vodikovih i halogenskih veza, Keesomovih i Londonovih sila itd. <br />Kokristalizacija je korisna u farmaceutskoj industriji jer omogućava promjenu fizikalno-kemijskih svojstava farmakološki aktivnih tvari bez mijenjanja njihove molekulske strukture.
Example sentences:
Kokristali s antranilnom i benzojevom kiselinom dosad nisu bili poznati u literaturi i okarakterizirani su uz pomoć difrakcije rendgenskih zraka na praškastim uzorcima i uz pomoć Ramanove spektroskopije. (CROSBI)
Kako bi se izučila mogućnost priprave supramolekulskih arhitektura temeljem halogenske veze Co-Cl···I u kokristalima koji sadrže metaloorganske jedinke CoCl2L2 i perhalogenirane spojeve, istraživanje doktorandice Lisac uključuje organsku, metaloorgansku i supramolekulsku sintezu te termalnu, spektroskopsku i strukturnu analizu materijala metodom difrakcije rentgenskih zraka. (HRZZ)
Soli, solvati i kokristali pripadaju u višekomponentne molekulske kristale, a razlikuju se po vrsti molekula od kojih se kristal sastoji. Kokristali i solvati se uvijek sastoje od nenabijenih molekula, dok se soli sastoje od nabijenih. Prema strogoj definiciji glavna razlika između solvata i kokristala je ta što je barem jedna komponenta koja ulazi u sastav solvata pri sobnoj temperaturi tekućina (odnosno otapalo), dok su kod kokristala sve komponente koje ulaze u njegov sastav pri sobnoj temperaturi čvrste tvari. (PMF)
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