English to Russian Science Mathematics & Statistics

We used linear mixed models as implemented in the GCTA package (Yang et al. (2011) Am J Hum Genet 88:76-82, herein incorporated by references in its entirety for all purposes) to test for association between trait residuals and single nucleotide variants.
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We then calculated trait residuals for all laboratory traits after adjustment for age, age2, sex, and the first ten principal components of ancestry, and applied appropriate transformations prior to association analysis.
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Analyses of association with transformed quantitative clinical measurement residuals were performed using linear regression, and analyses of association with clinical diagnoses were performed using logistic regression adjusted for age, age2, sex, and the first four principal components.