English to Russian Medical Medical (general) болезнь Грейвса, аутоиммунитет

Даю для ясности большой фрагмент контекста, а слово, которое под вопросом - в конце, в последнем предложении.

Both T cells and B cells, critical components of adaptive immunity, are necessary for the development of Graves’ disease. Thymic education of immune cells leads to the deletion of autoreactive T cells from the lymphocyte pool. These T cells show proliferative responses through antigen-specific interactions occurring between T-cell receptors and major-histocompatibility-complex (MHC) molecules on antigen-presenting cells such as dendritic cells, monocytes, and B cells. T cells rely on second signals, without which they become anergic. Some T cells differentiate into effector-cell phenotypes that have the functions of type 1, type 2, or type 17 helper T cells (Th1, Th2, or Th17). Others develop into regulatory T cells (e.g., regulatory T cells with the CD25+Foxp3+ phenotype), which can attenuate immune reactivity. Each phenotype produces a characteristic pattern of cytokines. The balance between proinflammatory factors and factors that dampen immune reactivity determines the amplitude and duration of immune responses. In Graves’ disease, autoreactive T cells against the thyrotropin receptor have escaped both central (thymic) and peripheral editing. Receptors on these CD4+ helper T cells interact with MHC class II molecules through which thyrotropin-receptor peptides are presented. Intrathyroidal T cells are particularly reactive to thyroid antigens and predominantly have the Th2 phenotype. However, the issue of whether Graves’ disease is biased to the Th1 or Th2 functional subset remains controversial. Variable-region gene use by clonally expanded intrathyroidal T cells IS BIASED as compared with peripheral-blood T cells.

Мой сырой вариант последнего предложения (который оставляет у меня ощущение непонимания происходящего):
Использование гена с вариабельными участками клонированными интратиреоидными Т-клетками искажается/смещается/перевешивается по сравнению с Т-клетками периферической крови.