English to Russian Medical Medical: Pharmaceuticals синопсис клинического исследования

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Контекст:
The primary hypothesis was assessed by a step-down trend test using linear contrasts, comparing
doses of MK-3102 to placebo at Week 12, from the above cLDA model. This step-down procedure
first included all doses of MK-3102 and placebo for the test of trend. If a statistically significant result
was observed, the highest dose group was deemed significantly different from placebo. Then the
highest dose is removed from the linear contrast and the trend test is repeated among remaining doses.
This statistical process proceeds in a stepwise fashion until lack of significance is observed to
determine the minimal effective dose that is statistically significantly different from placebo. This
step-down trend test is a closed testing procedure and preserves the overall Type I error rate for
testing the primary hypothesis.

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