English to Spanish Medical Medical: Pharmaceuticals

En un estudio titulado: "Potential negative cardiovascular effects of calcium supplements":

"Indeed, no increased cardiovascular risks were observed with calcium from food which is absorbed more slowly. Even the administration of a calcium supplement in the form of bone powder does not increase the plasma calcium level above normal [ref]. In the same way, calcium supplements increase slightly the risk of renal stones in some studies, whereas calcium from food decreases this risk [ref]. It might be assumed, therefore, in the light of the studies of xxx et al. [refs], that supplements of only 500 mg of calcium taken after a meal are harmless, even when taken twice a day.

The question remains if a supplement of 500 mg per day is enough. One could argue that a supplement of 500 mg of calcium does not meet the requirements, which were redefined recently by the Institute of Medicine in the USA (IOM) [ref]. The report states that 1,000 mg of calcium is the estimated average requirement for women over 50 years, and 1,200 mg/day is the recommended daily allowance. But these figures are derived from studies in populations whose bone health was not optimal. **These studies were not titrated against** the blood level of 25-hydroxyvitamin D. They were performed in populations that probably were—as we now know to be—vitamin D deficient."

Normalmente, traduciría "titrate" como "titulado" o "valorado" en el campo químico. He encontrado que en el caso de estudios clínicos, se menciona "ajuste de dosis de medicamento".

¿En este contexto, sería correcto decir "En estos estudios, la dosis de calcio no se ajustó de acuerdo a" la concentración sanguínea de 25-hidroxivitamina D"?

Mil gracias por adelantado.