timp de injumatatire

English translation: half-life

GLOSSARY ENTRY (DERIVED FROM QUESTION BELOW)
Romanian term or phrase:timp de injumatatire
English translation:half-life
Entered by: wordbridge

19:18 Apr 19, 2013
Romanian to English translations [PRO]
Medical - Medical: Pharmaceuticals
Romanian term or phrase: timp de injumatatire
explicatie din wikipedia: Timpul de injumătățire reprezintă un parametru farmacocinetic, fiind definit ca timpul necesar scăderii la jumătate a concentrației unei substanțe active, medicament în plasmă. El este influețat la început de modul de distribuție a medicamentului iar apoi predominant de epurarea sa.

context:
În SUA, într-un incendiu de la o clinică din Cleveland, în 1929, este evocat rolul cianurilor, ca urmare a inhalării vaporilor nitroşi degajaţi de combustia filmelor radiologice. Rolul acestor cianuri va fi mult timp neglijat din cauza timpului de înjumătăţire scurt, dozajele fiind realizate cu întârziere pe cadavre.
wordbridge
Romania
Local time: 14:33
half-life
Explanation:
A biological half-life or elimination half-life is the time it takes for a substance (drug, radioactive nuclide, or other) to lose one-half of its pharmacologic, physiologic, or radiological activity. In a medical context, the half-life may also describe the time that it takes for the concentration in blood plasma of a substance to reach one-half of its steady-state value (the "plasma half-life").

The relationship between the biological and plasma half-lives of a substance can be complex, due to factors including accumulation in tissues, active metabolites, and receptor interactions.[
Selected response from:

Angela Öhrman
Sweden
Local time: 13:33
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4 KudoZ points were awarded for this answer



Summary of answers provided
5half-life
Angela Öhrman
3half life
Claudia Coja


Discussion entries: 1





  

Answers


8 mins   confidence: Answerer confidence 5/5
half-life


Explanation:
A biological half-life or elimination half-life is the time it takes for a substance (drug, radioactive nuclide, or other) to lose one-half of its pharmacologic, physiologic, or radiological activity. In a medical context, the half-life may also describe the time that it takes for the concentration in blood plasma of a substance to reach one-half of its steady-state value (the "plasma half-life").

The relationship between the biological and plasma half-lives of a substance can be complex, due to factors including accumulation in tissues, active metabolites, and receptor interactions.[


Angela Öhrman
Sweden
Local time: 13:33
Native speaker of: Romanian
PRO pts in category: 4
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5 mins   confidence: Answerer confidence 3/5Answerer confidence 3/5
half life


Explanation:
http://sonet.nottingham.ac.uk/rlos/bioproc/halflife/
The duration of action of a drug is known as its half life. This is the period of time required for the concentration or amount of drug in the body to be reduced by one-half. We usually consider the half life of a drug in relation to the amount of the drug in plasma. A drug’s plasma half-life depends on how quickly the drug is eliminated from the plasma. A drug molecule that leaves plasma may have any of several fates. It can be eliminated from the body, or it can be translocated to another body fluid compartment such as the intracellular fluid or it can be destroyed in the blood. The removal of a drug from the plasma is known as clearance and the distribution of the drug in the various body tissues is known as the volume of distribution. Both of these pharmacokinetic parameters are important in determining the half life of a drug.

Here is the symbol to represent the half-life: t½

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Note added at 11 mins (2013-04-19 19:29:40 GMT)
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TIMP DE INJUMATATIRE TIMP DE INJUMATATIRE / demi-vie, s. f. / half-life.
http://www.dictio.ro/medical/timp-de-injumatatire

Claudia Coja
Local time: 13:33
Works in field
Native speaker of: Native in RomanianRomanian
PRO pts in category: 24
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