local reading

English translation: local reading

21:59 Aug 17, 2017
English language (monolingual) [PRO]
Medical - Medical: Pharmaceuticals
English term or phrase: local reading
What is the exact meaning of the term "local reading" in the following: At the time of study treatment code unblinding, patients who choose to receive open-label [name of test drug] will have a start of open-label treatment visit and will visit the study centre every X weeks until metastasis is seen by local reading.
This is from a clinical trial protocol.

Thanks for your help!
Rita Vaicekonyte
Lithuania
Selected answer:local reading
Explanation:
It means a local reading in opposite to a central reading. The local reading is performed in the investigators site. Nevertheless, for some procedures like imagenologic studies, EKG, etc., it is mandatory to perform a central reading so just one trained (and blinded) person performs the evaluations. I hope I explained it clearly.

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Note added at 4 hrs (2017-08-18 02:50:24 GMT)
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PS: The central reading is done by somebody assigned by the Sponsor, unrelated to the investigative sites.
Selected response from:

Rosario Gulias
Mexico
Grading comment
Selected automatically based on peer agreement.
4 KudoZ points were awarded for this answer



SUMMARY OF ALL EXPLANATIONS PROVIDED
5 +5local reading
Rosario Gulias
3 +2the on-site (local) analysis department
David Hollywood


  

Answers


9 mins   confidence: Answerer confidence 3/5Answerer confidence 3/5 peer agreement (net): +2
the on-site (local) analysis department


Explanation:
I'm a native speaker but even so not sure about this. I think it could refer to the department resposible for interpreting the results

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Note added at 10 mins (2017-08-17 22:09:44 GMT)
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"reading" would indicate "analysis" or "interpretation"

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Note added at 11 mins (2017-08-17 22:10:30 GMT)
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maybe your full context will help you further

David Hollywood
Local time: 18:02
Native speaker of: English

Peer comments on this answer (and responses from the answerer)
agree  Sabine Akabayov, PhD: or analysis in the local laboratory
12 mins
  -> vielen Dank Sabine ... ich bin mir überhaupt nicht sicher in diesem Zusammenhang, aber scheint zu passen thanks Sabine and not sure at all if this fits in the context but seems to

agree  acetran
20 days
Login to enter a peer comment (or grade)

4 hrs   confidence: Answerer confidence 5/5 peer agreement (net): +5
local reading


Explanation:
It means a local reading in opposite to a central reading. The local reading is performed in the investigators site. Nevertheless, for some procedures like imagenologic studies, EKG, etc., it is mandatory to perform a central reading so just one trained (and blinded) person performs the evaluations. I hope I explained it clearly.

--------------------------------------------------
Note added at 4 hrs (2017-08-18 02:50:24 GMT)
--------------------------------------------------

PS: The central reading is done by somebody assigned by the Sponsor, unrelated to the investigative sites.

Rosario Gulias
Mexico
Specializes in field
Native speaker of: Spanish
PRO pts in category: 4
Grading comment
Selected automatically based on peer agreement.
Notes to answerer
Asker: Thank you, Rosario. It is indeed the opposite of a central reading and is carried out at the study site, as I found out in another part of the document.


Peer comments on this answer (and responses from the answerer)
agree  Tina Vonhof (X): Good explanation.
1 hr
  -> Thanks! :)

agree  Daryo
12 hrs

agree  Majid Wahab: Good explanation
5 days

agree  acetran
20 days

agree  Jörgen Slet
38 days
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