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calcium linked to receptor-PG synthesis coupling

Russian translation: см.

GLOSSARY ENTRY (DERIVED FROM QUESTION BELOW)
English term or phrase:calcium linked to receptor-PG synthesis coupling
Russian translation:см.
Entered by: Julia Berezina

08:33 Apr 9, 2021
English to Russian translations [PRO]
Medical - Medical: Pharmaceuticals / Pharmacology Written Summ
English term or phrase: calcium linked to receptor-PG synthesis coupling
Benzydamine was a very weak inhibitor of spontaneous PGI2 and PGE2 synthesis by human and rat gastric mucosa and rat kidney.
In contrast, benzydamine was a potent inhibitor of noradrenaline- and carbachol-stimulated (but not arachidonate- or trauma-stimulated) PGI2 synthesis.
It was concluded a) that benzydamine is unlikely to elicit cyclooxygenase-mediated side effects on the gastrointestinal tract or kidney, b) that the anti-inflammatory action of benzydamine is mediated by disruption of calcium linked to receptor-PG synthesis coupling and c) that calcium-dependent inflammatory processes may also be affected by benzydamine.
Julia Berezina
Local time: 18:39
см.
Explanation:
disruption of calcium linked to receptor-PG synthesis coupling - нарушение Ca-зависимого механизма индукции синтеза простагландинов при активации рецепторов
(букв. кальций, связанный с сопряжением [активации] рецепторов и синтеза простагландинов)
возможно получится сформулировать изящнее, но общий смысл таков

См. цитаты из первоисточника фразы
Both noradrenaline- and carbachol-stimulated PG synthesis in these tissues is linked to the mobilization of calcium (which in turn activates PLA2 which liberates AA from endogenous stores) whereas trauma and arachidonate stimulate PG synthesis by bypassing this intrinsic receptor-linked calcium-mobilization step [12]. Thus, it is possible that benzydamine, as with other NSAIDs, inhibits the mobilization of calcium stores linked to PLA2 activation. This conclusion is also in general agreement with Loftier et al. [24] who demonstrated that benzydamine inhibited the release of fatty acids from phospholipids at concentrations similar to those found to inhibit agonist-stimulated PG synthesis in this study.
...
The anti-inflammatory action of benzydamine is probably not due to inhibition of cyclooxygenase but possibly to disruption of calcium mobilization/sequestration linked to PG synthesis at the plasma membrane of inflammatory cells. Furthermore, since calcium is a universal second messenger, benzydamine may inhibit other calcium-dependent pro-inflammatory events (e.g. histamine release from mast cells).
https://link.springer.com/article/10.1007/BF02735396
Selected response from:

Igor Andreev
Local time: 18:39
Grading comment
4 KudoZ points were awarded for this answer



Summary of answers provided
3см.
Igor Andreev


  

Answers


3 hrs   confidence: Answerer confidence 3/5Answerer confidence 3/5
calcium linked to receptor-pg synthesis coupling
см.


Explanation:
disruption of calcium linked to receptor-PG synthesis coupling - нарушение Ca-зависимого механизма индукции синтеза простагландинов при активации рецепторов
(букв. кальций, связанный с сопряжением [активации] рецепторов и синтеза простагландинов)
возможно получится сформулировать изящнее, но общий смысл таков

См. цитаты из первоисточника фразы
Both noradrenaline- and carbachol-stimulated PG synthesis in these tissues is linked to the mobilization of calcium (which in turn activates PLA2 which liberates AA from endogenous stores) whereas trauma and arachidonate stimulate PG synthesis by bypassing this intrinsic receptor-linked calcium-mobilization step [12]. Thus, it is possible that benzydamine, as with other NSAIDs, inhibits the mobilization of calcium stores linked to PLA2 activation. This conclusion is also in general agreement with Loftier et al. [24] who demonstrated that benzydamine inhibited the release of fatty acids from phospholipids at concentrations similar to those found to inhibit agonist-stimulated PG synthesis in this study.
...
The anti-inflammatory action of benzydamine is probably not due to inhibition of cyclooxygenase but possibly to disruption of calcium mobilization/sequestration linked to PG synthesis at the plasma membrane of inflammatory cells. Furthermore, since calcium is a universal second messenger, benzydamine may inhibit other calcium-dependent pro-inflammatory events (e.g. histamine release from mast cells).
https://link.springer.com/article/10.1007/BF02735396


Igor Andreev
Local time: 18:39
Native speaker of: Native in RussianRussian
PRO pts in category: 625
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