heads up

Russian translation: открытая конформация

GLOSSARY ENTRY (DERIVED FROM QUESTION BELOW)
English term or phrase:heads up
Russian translation:открытая конформация
Entered by: Elena Shtronda

20:51 Jan 9, 2021
English to Russian translations [PRO]
COVID-19 - Medical - Medical: Pharmaceuticals
English term or phrase: heads up
SARS Cov-2 full-length, P2 mutant, "heads up", prefusion spike glycoprotein
Elena Shtronda
Ukraine
Local time: 11:41
открытая конформация
Explanation:
Так понимаю, речь о характеристиках вакцины?

антитела к вирусу с открытой конформацией S-белка

см.

Структура и конформационная изменчивость S-белка
https://tinyurl.com/y2t93p6q

To further structurally characterize the P2 spike protein, a cryo-electron microscopy (cryoEM) investigation of purified P2 S, expressed from DNA, was conducted. The cryoEM revealed, according to the Applicant, a particle population closely resembling the prefusion conformation of SARS-CoV-2 spike protein. By fitting a previously published atomic model on to a processed and refined cryoEM dataset, a rebuilt model was obtained showing good agreement with reported structures of prefusion full-length wild type S and its ectodomain with P2 mutations. In the prefusion state the RBD undergo hinge-like conformational movements and can either be in an “up” position (open for receptor binding) or in a “down” position (closed for receptor binding). Three-dimensional classification of the dataset showed a class of particles that was in the conformation one RBD ‘up’ and two RBD ‘down”. This partly open conformation represented 20.4% of the trimeric molecules. The remainder were in the all RBD ‘down’ conformation. Although potent neutralizing epitopes have been described when the RBD is in the “heads down” closed conformation, the “heads up” receptor accessible conformation exposes a potentially greater breadth of neutralizing antibody targets. It is concluded that antibodies to both the up and down conformations will potentially be formed upon immunisation with the P2 S encoding BNT162b2.
https://www.ema.europa.eu/en/documents/assessment-report/com...

К тому времени, когда антитела выработались в нужном для нейтрализации вируса титре к вирусу с открытой конформацией S-белка, вирус с закрытой конформацией S-белка может дать о себе знать. При этом он может составлять только малую часть вирусной нагрузки при начальном заражении. Однако нейтрализующие антитела к
открытой конформации S-белка, достигнув высокой концентрации, начнут находить этот вирус с закрытой конформацией S-белка и образовывать с ним нестабильные комплексы.
https://www.elibrary.ru/download/elibrary_43002901_50235726....
Selected response from:

Igor Andreev
Local time: 11:41
Grading comment
Большое спасибо за помощь!
4 KudoZ points were awarded for this answer



Summary of answers provided
4 +1открытая конформация
Igor Andreev
4внимание!
Michael Sarni


  

Answers


50 mins   confidence: Answerer confidence 4/5Answerer confidence 4/5 peer agreement (net): +1
открытая конформация


Explanation:
Так понимаю, речь о характеристиках вакцины?

антитела к вирусу с открытой конформацией S-белка

см.

Структура и конформационная изменчивость S-белка
https://tinyurl.com/y2t93p6q

To further structurally characterize the P2 spike protein, a cryo-electron microscopy (cryoEM) investigation of purified P2 S, expressed from DNA, was conducted. The cryoEM revealed, according to the Applicant, a particle population closely resembling the prefusion conformation of SARS-CoV-2 spike protein. By fitting a previously published atomic model on to a processed and refined cryoEM dataset, a rebuilt model was obtained showing good agreement with reported structures of prefusion full-length wild type S and its ectodomain with P2 mutations. In the prefusion state the RBD undergo hinge-like conformational movements and can either be in an “up” position (open for receptor binding) or in a “down” position (closed for receptor binding). Three-dimensional classification of the dataset showed a class of particles that was in the conformation one RBD ‘up’ and two RBD ‘down”. This partly open conformation represented 20.4% of the trimeric molecules. The remainder were in the all RBD ‘down’ conformation. Although potent neutralizing epitopes have been described when the RBD is in the “heads down” closed conformation, the “heads up” receptor accessible conformation exposes a potentially greater breadth of neutralizing antibody targets. It is concluded that antibodies to both the up and down conformations will potentially be formed upon immunisation with the P2 S encoding BNT162b2.
https://www.ema.europa.eu/en/documents/assessment-report/com...

К тому времени, когда антитела выработались в нужном для нейтрализации вируса титре к вирусу с открытой конформацией S-белка, вирус с закрытой конформацией S-белка может дать о себе знать. При этом он может составлять только малую часть вирусной нагрузки при начальном заражении. Однако нейтрализующие антитела к
открытой конформации S-белка, достигнув высокой концентрации, начнут находить этот вирус с закрытой конформацией S-белка и образовывать с ним нестабильные комплексы.
https://www.elibrary.ru/download/elibrary_43002901_50235726....

Igor Andreev
Local time: 11:41
Native speaker of: Native in RussianRussian
PRO pts in category: 625
Grading comment
Большое спасибо за помощь!

Peer comments on this answer (and responses from the answerer)
agree  Marlin31: //Спасибо Игорь! Также с праздниками!
9 hrs
  -> Спасибо, Александр! С Новым годом!
Login to enter a peer comment (or grade)

2 hrs   confidence: Answerer confidence 4/5Answerer confidence 4/5
внимание!


Explanation:
Ср.
Thanks for the heads up on the credit card.
Спасибо за предупреждение о кредитной карте.
A simple heads up, that's all I needed.
Простое предупреждение, это всё, что мне было нужно.
(Reverso)

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Note added at 2 hrs (2021-01-09 23:04:56 GMT)
--------------------------------------------------

Или сходное: «осторожно!»

Michael Sarni
United Kingdom
Local time: 09:41
Native speaker of: Native in RussianRussian
PRO pts in category: 16
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