per local review

French translation: évaluation locale

GLOSSARY ENTRY (DERIVED FROM QUESTION BELOW)
English term or phrase:per local review
French translation:évaluation locale
Entered by: NikkoTh

09:18 Nov 11, 2020
English to French translations [PRO]
Science - Medical (general)
English term or phrase: per local review
Product X Intra-patient Dose Escalation (IPDE) Following Disease Progression Provides Clinically Meaningful Progression-Free Survival (PFS) in Gastrointestinal Stromal Tumor (GIST) in Phase 1 Study
Patients may dose escalate from Product X 150 mg QD to Product X 150 mg BID after disease progression*
Escalation and Expansion with GIST Patients
Product X 150 mg QD (28 day cycles)
N = 142
Disease progression per local review
Intra-Patient Dose Escalation (IPDE) to Product X 150 mg BID
N = 67
Efficacy Endpoint
PFS (per RECIST v1.1 based on local review)*
PFS 1:
Progression-free survival on Product X 150 mg QD defined as Cycle 1, Day 1 to progression
NikkoTh
évaluation locale
Explanation:
autre possibilité

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Note added at 4 heures (2020-11-11 14:02:11 GMT)
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par une évaluation locale
Selected response from:

orgogozo
France
Local time: 12:23
Grading comment
4 KudoZ points were awarded for this answer



Summary of answers provided
3 +2évaluation locale
orgogozo
3par examen local
Nathalie Stewart


  

Answers


1 hr   confidence: Answerer confidence 3/5Answerer confidence 3/5
par examen local


Explanation:

As far as I understand, in clinical trials there can be central review (for ex. blinded independent central review, BICR) or local review (by the site investigator). This study is in the second situation.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2654812/

[...] The US Food and Drug Administration has suggested censoring such cases; however, this is problematic. This type of censoring will be informative—patients who progress according to local review (but not according to central review) will be more likely to progress by the next scheduled scan than patients who have not been determined to progress by local review.

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Note added at 1 hr (2020-11-11 10:27:24 GMT)
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In French:
https://www.kusajili.fr/Trial/Is-7g6-7rESlRuC9yhMHvA$etude-nct03693170-etude-de-phase-2-evaluant-lefficacite-et-la-securite-de-lencorafenib-associe-a-du-binimetinib-et-a-du-cetuxim

[...] Évaluer le temps de réponse par un examen local et central. Évaluer la survie sans progression par un examen local et central.

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Note added at 1 hr (2020-11-11 10:34:58 GMT)
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> In your context - it seems this is part of a list or a table of results, correct? So you may want something more concise and factual, rather than describing a process:
Progression de la maladie selon examen local

Nathalie Stewart
France
Specializes in field
Native speaker of: Native in EnglishEnglish, Native in FrenchFrench
PRO pts in category: 60
Login to enter a peer comment (or grade)

4 hrs   confidence: Answerer confidence 3/5Answerer confidence 3/5 peer agreement (net): +2
évaluation locale


Explanation:
autre possibilité

--------------------------------------------------
Note added at 4 heures (2020-11-11 14:02:11 GMT)
--------------------------------------------------

par une évaluation locale

orgogozo
France
Local time: 12:23
Specializes in field
Native speaker of: Native in FrenchFrench
PRO pts in category: 178

Peer comments on this answer (and responses from the answerer)
agree  Lionel-N
1 hr
  -> Merci Lionel

agree  Drmanu49
4 hrs
  -> Merci Drmanu
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